Premature Ageing Disease and Late Onset Diesease
Werner syndrome is one of the best studies progeriod syndromes. It is considered an excellent model for human ageing (Cheng et al, 2007). Patients with Werner syndrome exhibit accelerated ageing and the common phenotypes associated with ageing. In this disease the WRN gene is mutated mainly through chromosomal translocations and this results in the production of a dysfunctional WRN protein (which has multiple roles in DNA metabolism).
