How Oxidative Stress Is Implicated In Ageing: Part 2
When lipids are oxidised by Reactive oxygen species, the resultant products can have a variety of affects on an organism. For example, Malonaldehyde (a lipid oxidation product) is capable of reacting with various molecules (proteins, nucleic acids) and can alter their structural confirmation. This alteration then leads to the immobilization of immune function. Furthermore researchers have found that many sufferers of age related diseases such as liver disease, diabetes and atherosclerosis, have high levels of lipid oxidation products present in cells (Lee, 2004). Frei (1995) also noted that the oxidation of LDLs can lead to the development of cardiovascular disease.
